•Defined as a life-threatening, generalized maldistribution of blood flow resulting in failure to deliver and/or utilize adequate amounts of oxygen, leading to tissue dysoxia
•Hypotension (SBP < 90, SBP decrease of 40 mmHg from baseline, or mean arterial pressure (MAP <65), while commonly present, should NOT be required to define shock
•In the absence of hypotension, when shock is suggested by history and physical examination, we recommend that a marker of inadequate perfusion be measured (decreased ScvO2, SvO2, increased blood lactate, increased base deficit, perfusionrelated low pH)
Septic Shock: Sepsis with Hypotension
•If hypotension resolves after recommended 30 cc/kg fluid bolus then diagnose severe sepsis
•If hypotension persists after recommended 30 cc/kg fluid bolus then diagnose septic shock and begin Levophed (preferred pressor)
•If Lactic acid > 4.0 with sepsis then diagnose septic shock and treat as septic shock
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